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KMID : 0359920110300020211
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Korean Journal of Nephrology
2011 Volume.30 No. 2 p.211 ~ p.214
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A Case of Baclofen-Induced Encephalopathy in a Patient with ESRD on Continuous Ambulatory Peritoneal Dialysis
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Kim Eun-Hye
Kim Bun
Lee Su-Jin
Kim Min-Hyung
Kang Shin-Wook
Choi Kyu-Hun
Yoo Tae-Hyun
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Abstract
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Baclofen (β-4-chlorophenyl-γ-aminobutyric acid), a gamma-aminobutyric acid (GABA) derivative, is commonly used for relief of spinal-origin spasm or pain. Baclofen is eliminated predominantly by the kidneys, putting patients with impaired renal function at particular risk for baclofen accumulation. The authors report on a case of baclofen-induced encephalopathy in a patient on continuous ambulatory peritoneal dialysis (CAPD). A 56 year old patient with ESRD on CAPD was admitted due to stuporous mental status after baclofen treatment. Brain imaging showed no specific abnormality. After intensive treatment of CAPD for 3 days, neurologic abnormality was completely recovered. Baclofen should not be recommended for patients with renal dysfunction. Although the best-known treatment choice for baclofen toxicity is hemodialysis, intensive CAPD can also be considered as an option for treatment of baclofen toxicity.
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KEYWORD
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Baclofen, Encephalopathy, Continuous ambulatory peritoneal dialysis
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